The biology of the immunoregulatory cytokines IFNγ, IL-18, and IL-22
H. Mühl (group leader), M. Bachmann (staff scientist), S. Gonther (PhD student), H. Stülb (PhD student), A. Ahmed (MD student), S. Rösser (Master student)
Most diseases accompanied with inflammation, autoimmunity, and infection are associated with changes in cytokine, chemokine, and growth factor production. We investigate roles of these mediators related to the processes of inflammation and carcinogenesis.
In particular, we study the biology of cytokines and mediators that are associated with Th1-like inflammation with focus on IFNγ, IL-22, the IL-1 family of cytokines, and nitric oxide.
Supported by DFG (DFG MU 1284/6-2)
und GRK 2336: AVE - Resolution of Inflammation
Selected Original Publications
Bachmann M, Pfeilschifter J, and Mühl H. Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. BBA-GENE REGUL MECH, 1861(3): 191-199, 2018
Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 9: 161. doi: 10.3389/fimmu.2018.00161. eCollection 2018
Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017
Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, and Mühl H. Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. Am J Pathol., 182(4):1107-13, 2013
Bachmann M, Ulziibat S, Härdle L, Pfeilschifter J, and Mühl H. IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Biochem Pharmacol., 85(3): 396-403, 2013
Kronenberger B, Rudloff I, Bachmann M, Brunner F, Kapper L, Filmann N, Waidmann O, Herrmann E, Pfeilschifter J, Zeuzem S, Piiper A, and Mühl H. Interleukin-22 predicts severity and death in advanced liver cirrhosis: A prospective cohort study.
BMC Medicine, 10 (1), 102, 2012
Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, and Mühl H. IL36γ/IL1F9 - an innate T-bet target in myeloid cells.
J Biol Chem., 287(50): 41684-96, 2012
Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, and Mühl H. Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and IL-1. PLoS Pathogens, 14;6(10):e1001144, 2010
Sadik CD, Bachmann M, Pfeilschifter J, and Mühl H. Activation of interferon regulatory factor-3 via Toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Nucleic Acids Res, 37(15):5041-56, 2009